CROSSTALK AND ULTRASENSITIVITY IN PROTEIN DEGRADATION PATHWAYS.

Crosstalk and ultrasensitivity in protein degradation pathways.

Protein turnover is vital to cellular homeostasis.Many proteins are degraded efficiently only after they have been post-translationally "tagged" with a polyubiquitin chain.Ubiquitylation is a form of Outdoor Lighting Post-Translational Modification (PTM): addition of a ubiquitin to the chain is catalyzed by E3 ligases, and removal of ubiquitin is c

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Construction of store-operated calcium entry-related gene signature for predicting prognosis and indicates immune microenvironment infiltration in stomach adenocarcinomas

Abstract Gastric adenocarcinoma (STAD) is the most prevalent Accessories malignancy of the human digestive system and the fourth leading cause of cancer-related death.Calcium pools, especially Ca2+ entry (SOCE) for storage operations, play a crucial role in maintaining intracellular and extracellular calcium balance, influencing cell activity, and

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